A number of police officers are feared injured in the attack on the Police station, which is located around the palace of the Emir of Kano.
Eyewitnesses said the gunmen had arrived on a motorcycles at about 7.42 am and launched an attack on the station causing pandemonium among residents.
Mandawari station had been the target of several attacks by unknown gunmen in the last couple of weeks.
The Joint Military Task force (JTF) in the state has cordoned off the area and searching for suspect.
However, the attacks are said to be spreading to other parts of the ancient town, as the gunfights are still ongoing between the militants and security operatives.
Kano witnessed a similar attack last Friday when unknown gunmen attacked Rijiyar’zaki police station where one Ali Sadiq was shot dead in a cross fire.
The police Image maker in Kano, Magaji Musa Majia has confirmed the incident.